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OPTISOLV® Technology
The dual-coating technology for natural ingredients
Many natural ingredients repel water and crystallise, which limits their absorption in the intestinal tract. OPTISOLV® Technology encapsulates them at a molecular level in two natural layers and turns them into crystal-free, free-flowing powders.
Why native actives fall short
Two barriers between a plant and the body
Barrier 01
Hydrophobic molecules
Polyphenols, flavonoids, boswellic acids and alkaloids are poorly water-soluble. In the aqueous environment of the gut they stay largely undissolved.
Barrier 02
Crystalline structure
Native extracts form densely packed crystal structures. Release during digestion is slow and incomplete, so brands compensate with high doses.
How it works
How the dual coating works
Active core
The natural ingredient, held in a stable, crystal-free state.
Inner layer: cyclodextrin
Ring-shaped starch molecules form inclusion complexes with the active and improve its water solubility.
Outer layer: phospholipids
Sunflower lecithin ensures stable release over time, supports permeability across the intestinal wall and masks taste.
What changes in the gut
Native actives dissolve poorly, which limits their absorption in the intestinal tract. Crystal-free, dual-coated OPTISOLV® actives show superior solubility, dissolution and permeability.
Native vs. OPTISOLV®
Same plant. Different performance.
Native extract
OPTISOLV® active
Physical form
Crystalline, densely packed
Crystal-free, dual-coated
Water solubility
Very low
Over 1000× (curcumin), over 110× (boswellia), over 10× (passionflower)
Release during digestion
Slow and incomplete
Up to 170× (curcumin), up to 44× (boswellia), best-in-class (berberine)
Absorption, human intestinal cell model
Reference
13.4× (berberine), 3.7× (passionflower)
Dose
High, often several times a day
Lower, e.g. 250-500 mg berberine instead of 1,000-1,500 mg
Taste
Often bitter or unpleasant
Significantly masked, 72 % preferred OPTISOLV® Passiflora
Excipients
–
Gamma-cyclodextrin and sunflower lecithin, no synthetic emulsifiers
Formats
Limited by dose and taste
Powders, capsules, tablets, stick packs, sachets, gummies, chewing tablets
In vitro data from EVANIUM lab studies (saturation solubility in water, dissolution in biorelevant media, Caco-2 cell model) and an external consumer study. Methods on the ingredient pages.
What formulators get
Six reasons to work with OPTISOLV®
Water-soluble
Hydrophobic actives dissolve in aqueous media, measured against the native extracts.
Faster release
Release speed and amount improved by up to 170× in simulated intestinal fluid.
High absorption
Up to 13.4× higher absorption in a human intestinal cell model, enabling lower doses.
Natural
Cyclodextrins and phospholipids only. No synthetic emulsifiers, vegan, non-GMO.
Taste-masked
Bitter and unpleasant botanicals become usable in gummies, chewing tablets and drink powders.
Free-flowing powder
One powder for capsules, tablets, stick packs, sachets, gummies and chewing tablets.
Proven across four botanicals
One technology, four ingredients
Science in Regensburg
Developed in Germany. Produced in France.
Formulation and analytics happen in our two laboratories at the BioPark Regensburg. Every ingredient is characterised before it reaches a customer.
Analytics
HPLC, saturation solubility, dissolution in biorelevant gastric and intestinal fluids, Caco-2 cell model
IP
4 patent applications protect process and compositions
Production
Partner facility in France: HACCP, ISO 22000, FDA-registered
Scale
Over 5.5 t of material produced and sold
Free whitepaper
The Bioavailability Gap
How overlooked formulation challenges are constraining innovation across nutraceuticals, with berberine as a case study.
FAQ
Questions about OPTISOLV® Technology
What is OPTISOLV® Technology?
OPTISOLV® Technology is EVANIUM’s IP-protected dual-coating technology for natural ingredients. An inner layer of gamma-cyclodextrin improves solubility, an outer layer of phospholipids ensures stable release, supports permeability and masks taste. The result is a crystal-free, free-flowing powder.
Which excipients does it use?
Natural excipients only: gamma-cyclodextrin and sunflower lecithin. OPTISOLV® ingredients contain no synthetic emulsifiers.
Which dosage forms are possible?
OPTISOLV® ingredients are free-flowing powders for powders, capsules, tablets, stick packs, sachets, gummies and chewing tablets, depending on the ingredient.
Can OPTISOLV® Technology be applied to other actives?
OPTISOLV® Technology is designed for natural ingredients. Tell us about your molecule and our formulation team will assess whether OPTISOLV® can help.
Have a difficult active?
Tell us about your molecule. Our formulation team will assess whether OPTISOLV® Technology can help.